BDBM103655 US8563553, 80

SMILES: CCCS(=O)(=O)Nc1ccc(F)c(-c2[nH]c(nc2-c2ccnc(NC[C@H](C)NC(=O)OC)n2)C2CC2)c1Cl

InChI Key: InChIKey=OXYPKVAZLSIWCF-ZDUSSCGKSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 103655   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase B-raf [V600E] (Homo sapiens (Human))	BDBM103655 (US8563553, 80) Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(-c2[nH]c(nc2-c2ccnc(NC[C@H](C)NC(=O)OC)n2)C2CC2)c1Cl |r,wU:25.26,(-5.86,4.43,;-4.77,3.35,;-3.28,3.74,;-2.2,2.66,;-1.11,3.74,;-3.28,1.57,;-1.11,1.57,;.38,1.96,;.78,3.45,;2.27,3.85,;3.36,2.76,;4.84,3.16,;2.96,1.27,;4.05,.19,;5.51,.66,;6.42,-.58,;5.51,-1.83,;4.05,-1.35,;2.71,-2.12,;2.71,-3.66,;1.38,-4.43,;.05,-3.66,;.05,-2.12,;-1.29,-1.35,;-2.62,-2.12,;-3.96,-1.35,;-3.96,.19,;-5.29,-2.12,;-6.62,-1.35,;-6.62,.19,;-7.96,-2.12,;-9.29,-1.35,;1.38,-1.35,;7.96,-.58,;9.29,-1.35,;9.29,.19,;1.47,.88,;1.07,-.61,)| Show InChI InChI=1S/C24H29ClFN7O4S/c1-4-11-38(35,36)33-16-8-7-15(26)18(19(16)25)21-20(31-22(32-21)14-5-6-14)17-9-10-27-23(30-17)28-12-13(2)29-24(34)37-3/h7-10,13-14,33H,4-6,11-12H2,1-3H3,(H,29,34)(H,31,32)(H,27,28,30)/t13-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.450	n/a	n/a	n/a	n/a	7.5	n/a
Novartis AG; IRM LLC US Patent					Assay Description Raf/Mek amplified luminescence proximity homogeneous assay.				US Patent US8563553 (2013) BindingDB Entry DOI: 10.7270/Q2ZP44R7
					More data for this Ligand-Target Pair