BDBM103873 US9695165, 56

SMILES: COc1cc(OC)c(Cl)c(c1Cl)-c1nc2cnc(cc2n(C2CCCC2)c1=O)-c1ccc2OCCN(C(=O)C=C)c2c1

InChI Key: InChIKey=STFGDNAMWSFVRE-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 103873   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM103873 (US9695165, 56) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1nc2cnc(cc2n(C2CCCC2)c1=O)-c1ccc2OCCN(C(=O)C=C)c2c1 |(3.85,9.24,;3.85,7.7,;2.52,6.93,;1.18,7.7,;-.15,6.93,;-1.48,7.7,;-2.82,6.93,;-.15,5.39,;-1.48,4.62,;1.18,4.62,;2.52,5.39,;3.85,4.62,;1.18,3.08,;2.52,2.31,;2.52,.77,;3.85,,;3.85,-1.54,;2.52,-2.31,;1.18,-1.54,;1.18,,;-.15,.77,;-1.48,,;-2.95,.48,;-3.85,-.77,;-2.95,-2.02,;-1.48,-1.54,;-.15,2.31,;-1.48,3.08,;2.52,-3.85,;3.85,-4.62,;3.85,-6.16,;2.52,-6.93,;2.52,-8.47,;1.18,-9.24,;-.15,-8.47,;-.15,-6.93,;-1.48,-6.16,;-1.48,-4.62,;-2.82,-6.93,;-2.82,-8.47,;1.18,-6.16,;1.18,-4.62,)| Show InChI InChI=1S/C31H28Cl2N4O5/c1-4-26(38)36-11-12-42-23-10-9-17(13-22(23)36)19-14-21-20(16-34-19)35-30(31(39)37(21)18-7-5-6-8-18)27-28(32)24(40-2)15-25(41-3)29(27)33/h4,9-10,13-16,18H,1,5-8,11-12H2,2-3H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair