BDBM103878 US10125133, Example 5::US10968221, Example 5::US9695167, 5

SMILES: Cc1ccc(cc1)-c1c(cc(-c2cccc(CN3CCC(N)C3)c2)c2ncnn12)-c1ccc(cc1)C#N

InChI Key: InChIKey=OTNUJQPXKKRFIH-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 103878   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Lysine-specific histone demethylase 1A (Homo sapiens (Human))	BDBM103878 (US10125133, Example 5 | US10968221, Example 5 | US...) Show SMILES Cc1ccc(cc1)-c1c(cc(-c2cccc(CN3CCC(N)C3)c2)c2ncnn12)-c1ccc(cc1)C#N Show InChI InChI=1S/C31H28N6/c1-21-5-9-25(10-6-21)30-28(24-11-7-22(17-32)8-12-24)16-29(31-34-20-35-37(30)31)26-4-2-3-23(15-26)18-36-14-13-27(33)19-36/h2-12,15-16,20,27H,13-14,18-19,33H2,1H3	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	75	n/a	n/a	n/a	n/a	7.5	25
Incyte Corporation US Patent					Assay Description LANCE LSD1/KDM1A demethylase assay¿10 uL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM Na...				US Patent US9695167 (2017) BindingDB Entry DOI: 10.7270/Q2XP7334
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A (Homo sapiens (Human))	BDBM103878 (US10125133, Example 5 | US10968221, Example 5 | US...) Show SMILES Cc1ccc(cc1)-c1c(cc(-c2cccc(CN3CCC(N)C3)c2)c2ncnn12)-c1ccc(cc1)C#N Show InChI InChI=1S/C31H28N6/c1-21-5-9-25(10-6-21)30-28(24-11-7-22(17-32)8-12-24)16-29(31-34-20-35-37(30)31)26-4-2-3-23(15-26)18-36-14-13-27(33)19-36/h2-12,15-16,20,27H,13-14,18-19,33H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	75	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description LANCE LSD1/KDM1A demethylase assay—10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...				US Patent US10968221 (2021)
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A (Homo sapiens (Human))	BDBM103878 (US10125133, Example 5 | US10968221, Example 5 | US...) Show SMILES Cc1ccc(cc1)-c1c(cc(-c2cccc(CN3CCC(N)C3)c2)c2ncnn12)-c1ccc(cc1)C#N Show InChI InChI=1S/C31H28N6/c1-21-5-9-25(10-6-21)30-28(24-11-7-22(17-32)8-12-24)16-29(31-34-20-35-37(30)31)26-4-2-3-23(15-26)18-36-14-13-27(33)19-36/h2-12,15-16,20,27H,13-14,18-19,33H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	75	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...				US Patent US10125133 (2018) BindingDB Entry DOI: 10.7270/Q2930W7B
					More data for this Ligand-Target Pair