BDBM103881 US10125133, Example 8::US10968221, Example 8::US9695167, 8

SMILES: CN(C)[C@H]1CCN(Cc2cc(-c3ccc(cc3)C#N)c(-c3ccc(C)cc3)n3ncnc23)C1

InChI Key: InChIKey=KNVJEZKCJUEQEG-DEOSSOPVSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 103881   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Lysine-specific histone demethylase 1A [151-852] (Homo sapiens (Human))	BDBM103881 (US10125133, Example 8 | US10968221, Example 8 | US...) Show SMILES CN(C)[C@H]1CCN(Cc2cc(-c3ccc(cc3)C#N)c(-c3ccc(C)cc3)n3ncnc23)C1 |r| Show InChI InChI=1S/C27H28N6/c1-19-4-8-22(9-5-19)26-25(21-10-6-20(15-28)7-11-21)14-23(27-29-18-30-33(26)27)16-32-13-12-24(17-32)31(2)3/h4-11,14,18,24H,12-13,16-17H2,1-3H3/t24-/m0/s1	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	7.5	25
Incyte Corporation US Patent					Assay Description LANCE LSD1/KDM1A demethylase assay¿10 uL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM Na...				US Patent US9695167 (2017) BindingDB Entry DOI: 10.7270/Q2XP7334
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A (Homo sapiens (Human))	BDBM103881 (US10125133, Example 8 | US10968221, Example 8 | US...) Show SMILES CN(C)[C@H]1CCN(Cc2cc(-c3ccc(cc3)C#N)c(-c3ccc(C)cc3)n3ncnc23)C1 |r| Show InChI InChI=1S/C27H28N6/c1-19-4-8-22(9-5-19)26-25(21-10-6-20(15-28)7-11-21)14-23(27-29-18-30-33(26)27)16-32-13-12-24(17-32)31(2)3/h4-11,14,18,24H,12-13,16-17H2,1-3H3/t24-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description LANCE LSD1/KDM1A demethylase assay—10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...				US Patent US10968221 (2021)
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A (Homo sapiens (Human))	BDBM103881 (US10125133, Example 8 | US10968221, Example 8 | US...) Show SMILES CN(C)[C@H]1CCN(Cc2cc(-c3ccc(cc3)C#N)c(-c3ccc(C)cc3)n3ncnc23)C1 |r| Show InChI InChI=1S/C27H28N6/c1-19-4-8-22(9-5-19)26-25(21-10-6-20(15-28)7-11-21)14-23(27-29-18-30-33(26)27)16-32-13-12-24(17-32)31(2)3/h4-11,14,18,24H,12-13,16-17H2,1-3H3/t24-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...				US Patent US10125133 (2018) BindingDB Entry DOI: 10.7270/Q2930W7B
					More data for this Ligand-Target Pair