null

SMILES: COC(=O)N(C)c1ccc(cc1F)-c1c(nc(OC[C@@H]2CCCN(C)C2)c2cncn12)-c1ccc(cc1)C#N

InChI Key: InChIKey=CCCHNENAEDSNAJ-HXUWFJFHSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 105544   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Lysine-specific histone demethylase 1A [151-852] (Homo sapiens (Human))	BDBM105544 (US10047086, 87 | US10640503, Example 87 | US969516...) Show SMILES COC(=O)N(C)c1ccc(cc1F)-c1c(nc(OC[C@@H]2CCCN(C)C2)c2cncn12)-c1ccc(cc1)C#N |r| Show InChI InChI=1S/C29H29FN6O3/c1-34-12-4-5-20(16-34)17-39-28-25-15-32-18-36(25)27(26(33-28)21-8-6-19(14-31)7-9-21)22-10-11-24(23(30)13-22)35(2)29(37)38-3/h6-11,13,15,18,20H,4-5,12,16-17H2,1-3H3/t20-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	7.5	25
Incyte Corporation US Patent					Assay Description LANCE LSD1/KDM1A demethylase assay¿10 uL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM Na...				US Patent US9695168 (2017) BindingDB Entry DOI: 10.7270/Q2SX6BCD
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A (Homo sapiens (Human))	BDBM105544 (US10047086, 87 | US10640503, Example 87 | US969516...) Show SMILES COC(=O)N(C)c1ccc(cc1F)-c1c(nc(OC[C@@H]2CCCN(C)C2)c2cncn12)-c1ccc(cc1)C#N |r| Show InChI InChI=1S/C29H29FN6O3/c1-34-12-4-5-20(16-34)17-39-28-25-15-32-18-36(25)27(26(33-28)21-8-6-19(14-31)7-9-21)22-10-11-24(23(30)13-22)35(2)29(37)38-3/h6-11,13,15,18,20H,4-5,12,16-17H2,1-3H3/t20-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...				US Patent US10640503 (2020)
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A (Homo sapiens (Human))	BDBM105544 (US10047086, 87 | US10640503, Example 87 | US969516...) Show SMILES COC(=O)N(C)c1ccc(cc1F)-c1c(nc(OC[C@@H]2CCCN(C)C2)c2cncn12)-c1ccc(cc1)C#N |r| Show InChI InChI=1S/C29H29FN6O3/c1-34-12-4-5-20(16-34)17-39-28-25-15-32-18-36(25)27(26(33-28)21-8-6-19(14-31)7-9-21)22-10-11-24(23(30)13-22)35(2)29(37)38-3/h6-11,13,15,18,20H,4-5,12,16-17H2,1-3H3/t20-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	7.5	n/a
Incyte Corporation US Patent					Assay Description LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...				US Patent US10047086 (2018) BindingDB Entry DOI: 10.7270/Q28917W4
					More data for this Ligand-Target Pair