BDBM108053 4-((4-((2,3-dimethyl-2H-indazole-6-yl)(methyl) amino)pyrimidin-2-yl)amino)-N-(4-methylpyrimidin- 2-yl)benzenesulfonamide (P2d)
SMILES: CN(c1ccc2c(C)n(C)nc2c1)c1ccnc(Nc2ccc(cc2)S(=O)(=O)Nc2nccc(C)n2)n1
InChI Key: InChIKey=ZMSRESYSODUSBK-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase ABL1 (Homo sapiens (Human)) | BDBM108053 (4-((4-((2,3-dimethyl-2H-indazole-6-yl)(methyl) ami...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 62 | n/a | n/a | n/a | n/a | n/a | 25 |
Shandong Institute of Pharmaceutical Industry, Ji'nan, Shandong, 250101, China. | Assay Description To the assay kit, 2.5 µL of different concentrate of the test compounds, Pazopanib or water (control) were added and incubated for 1 h at room t... | Chem Biol Drug Des 83: 306-16 (2014) Article DOI: 10.1111/cbdd.12243 BindingDB Entry DOI: 10.7270/Q2PR7TM2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human)) | BDBM108053 (4-((4-((2,3-dimethyl-2H-indazole-6-yl)(methyl) ami...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | 25 |
Shandong Institute of Pharmaceutical Industry, Ji'nan, Shandong, 250101, China. | Assay Description To the assay kit, 2.5 µL of different concentrate of the test compounds, Pazopanib or water (control) were added and incubated for 1 h at room t... | Chem Biol Drug Des 83: 306-16 (2014) Article DOI: 10.1111/cbdd.12243 BindingDB Entry DOI: 10.7270/Q2PR7TM2 | |||||||||||
More data for this Ligand-Target Pair |