null
SMILES: C[C@H](N1CC[C@@](CC(C)(C)O)(OC1=O)c1ccccc1)c1ccc(cc1)-c1ccn2nc(C)nc2c1
InChI Key: InChIKey=XDOCJYNJFNBYOU-WRONEBCDSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human)) | BDBM108088![]() (US8598163, 56) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 31 | n/a | n/a | n/a | n/a | 6.0 | 37 |
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH US Patent | Assay Description The inhibition of a microsomal preparation of 11β-HSD1 in the presence of 50% human plasma by compounds of the invention was measured. | US Patent US8598163 (2013) BindingDB Entry DOI: 10.7270/Q29K48WR | |||||||||||
More data for this Ligand-Target Pair |