null

SMILES: CC(C)[C@@]1(CC(C)(C)O)CCN([C@@H](C)c2ccc(cc2)-c2ccc3nc(C)nn3c2)C(=O)O1

InChI Key: InChIKey=DERAIVBXARVNNP-QYBDOPJKSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 108093   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM108093 (US8598163, 5) Show SMILES CC(C)[C@@]1(CC(C)(C)O)CCN([C@@H](C)c2ccc(cc2)-c2ccc3nc(C)nn3c2)C(=O)O1 |r| Show InChI InChI=1S/C26H34N4O3/c1-17(2)26(16-25(5,6)32)13-14-29(24(31)33-26)18(3)20-7-9-21(10-8-20)22-11-12-23-27-19(4)28-30(23)15-22/h7-12,15,17-18,32H,13-14,16H2,1-6H3/t18-,26-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	7.4	n/a
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH US Patent					Assay Description The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...				US Patent US8598163 (2013) BindingDB Entry DOI: 10.7270/Q29K48WR
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM108093 (US8598163, 5) Show SMILES CC(C)[C@@]1(CC(C)(C)O)CCN([C@@H](C)c2ccc(cc2)-c2ccc3nc(C)nn3c2)C(=O)O1 |r| Show InChI InChI=1S/C26H34N4O3/c1-17(2)26(16-25(5,6)32)13-14-29(24(31)33-26)18(3)20-7-9-21(10-8-20)22-11-12-23-27-19(4)28-30(23)15-22/h7-12,15,17-18,32H,13-14,16H2,1-6H3/t18-,26-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	22	n/a	n/a	n/a	n/a	7.4	n/a
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH US Patent					Assay Description The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...				US Patent US8598163 (2013) BindingDB Entry DOI: 10.7270/Q29K48WR
					More data for this Ligand-Target Pair