BDBM109874 US8609647, 17

SMILES: O=C(CC#N)N1CCC11CCN(C1)c1ncnc2[nH]ccc12

InChI Key: InChIKey=LXGHRYUICAKWBN-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 109874   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM109874 (US8609647, 17) Show SMILES O=C(CC#N)N1CCC11CCN(C1)c1ncnc2[nH]ccc12 Show InChI InChI=1S/C15H16N6O/c16-5-1-12(22)21-8-4-15(21)3-7-20(9-15)14-11-2-6-17-13(11)18-10-19-14/h2,6,10H,1,3-4,7-9H2,(H,17,18,19)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	87	n/a	n/a	n/a	n/a	n/a	n/a
Japan Tobacco Inc. US Patent					Assay Description In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...				US Patent US8609647 (2013) BindingDB Entry DOI: 10.7270/Q29C6W24
					More data for this Ligand-Target Pair