BDBM109911 US8609647, 56

SMILES: FC1(F)CCN(C(=O)CC#N)C11CCCN(C1)c1ncnc2[nH]ccc12

InChI Key: InChIKey=AVIKPBMGOFXGTJ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 109911   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM109911 (US8609647, 56) Show SMILES FC1(F)CCN(C(=O)CC#N)C11CCCN(C1)c1ncnc2[nH]ccc12 Show InChI InChI=1S/C17H18F2N6O/c18-17(19)5-9-25(13(26)2-6-20)16(17)4-1-8-24(10-16)15-12-3-7-21-14(12)22-11-23-15/h3,7,11H,1-2,4-5,8-10H2,(H,21,22,23)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6.80	n/a	n/a	n/a	n/a	n/a	n/a
Japan Tobacco Inc. US Patent					Assay Description In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...				US Patent US8609647 (2013) BindingDB Entry DOI: 10.7270/Q29C6W24
					More data for this Ligand-Target Pair