BDBM109928 US8609647, 73

SMILES: O=C(N1CCCC11CCN(C1)c1ncnc2[nH]ccc12)C1(CC1)C#N

InChI Key: InChIKey=QTGVBNCYIIHLIO-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 109928   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM109928 (US8609647, 73) Show SMILES O=C(N1CCCC11CCN(C1)c1ncnc2[nH]ccc12)C1(CC1)C#N Show InChI InChI=1S/C18H20N6O/c19-10-17(4-5-17)16(25)24-8-1-3-18(24)6-9-23(11-18)15-13-2-7-20-14(13)21-12-22-15/h2,7,12H,1,3-6,8-9,11H2,(H,20,21,22)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	73	n/a	n/a	n/a	n/a	n/a	n/a
Japan Tobacco Inc. US Patent					Assay Description In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...				US Patent US8609647 (2013) BindingDB Entry DOI: 10.7270/Q29C6W24
					More data for this Ligand-Target Pair