BDBM110751 US8614206, 284

SMILES: Cc1ccc(F)c(c1)-c1nc(C(=O)Nc2cnn(C)c2N2CC[C@H](N)CC(F)(F)C2)c(N)s1

InChI Key: InChIKey=ONQRCCQTRXWVFT-LBPRGKRZSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 110751   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM110751 (US8614206, 284) Show SMILES Cc1ccc(F)c(c1)-c1nc(C(=O)Nc2cnn(C)c2N2CC[C@H](N)CC(F)(F)C2)c(N)s1 |r| Show InChI InChI=1S/C21H24F3N7OS/c1-11-3-4-14(22)13(7-11)19-29-16(17(26)33-19)18(32)28-15-9-27-30(2)20(15)31-6-5-12(25)8-21(23,24)10-31/h3-4,7,9,12H,5-6,8,10,25-26H2,1-2H3,(H,28,32)/t12-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.0150	n/a	n/a	n/a	n/a	n/a	n/a	7.2	n/a
F. Hoffmann-La Roche AG US Patent					Assay Description PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...				US Patent US8614206 (2013) BindingDB Entry DOI: 10.7270/Q2W66JFG
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