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SMILES: Cn1ncc(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)c1N1CCCC2(CCCN2)CC1

InChI Key: InChIKey=XANXSIGMXJYCQL-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 110802   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM110802
PNG
(US8614206, 351)
Show SMILES Cn1ncc(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)c1N1CCCC2(CCCN2)CC1
Show InChI InChI=1S/C23H27F2N7OS/c1-31-22(32-11-4-8-23(9-12-32)7-3-10-27-23)16(13-28-31)29-20(33)18-19(26)34-21(30-18)17-14(24)5-2-6-15(17)25/h2,5-6,13,27H,3-4,7-12,26H2,1H3,(H,29,33)
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KEGG

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Similars
US Patent
 0.0220n/an/an/an/an/an/a7.2n/a



F. Hoffmann-La Roche AG

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...

US Patent US8614206 (2013)


BindingDB Entry DOI: 10.7270/Q2W66JFG
More data for this
Ligand-Target Pair