BDBM11110 (2S)-1-{[(2S,5R)-5-(2,4-dichloro-5-nitrophenoxymethyl)pyrrolidin-2-yl]carbonyl}pyrrolidine-2-carbonitrile::2-cyanopyrrolidine 21aq
SMILES: [O-][N+](=O)c1cc(OC[C@H]2CC[C@H](N2)C(=O)N2CCC[C@H]2C#N)c(Cl)cc1Cl
InChI Key: InChIKey=ZERPCGGMVBYMLT-SUNKGSAMSA-N
Data: 1 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Dipeptidyl peptidase 4 (Homo sapiens (Human)) | BDBM11110 ((2S)-1-{[(2S,5R)-5-(2,4-dichloro-5-nitrophenoxymet...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 0.630 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories | Assay Description The DPP4 activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 355 nm and mea... | J Med Chem 49: 3520-35 (2006) Article DOI: 10.1021/jm051283e BindingDB Entry DOI: 10.7270/Q2WS8RG1 | |||||||||||
More data for this Ligand-Target Pair |