BDBM115189 N‐(3‐fluoro‐4‐methylphenyl)‐8‐methoxy‐2‐ (piperidine‐1‐carbonyl)quinolin‐4‐amine::UT-A1 inhibitor A8

SMILES: COc1cccc2c(Nc3ccc(C)c(F)c3)cc(nc12)C(=O)N1CCCCC1

InChI Key: InChIKey=BPGALXJEONUVTJ-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 115189   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Urea transporter B (UT-B) (Rattus norvegicus (Rat))	BDBM115189 (N‐(3‐fluoro‐4‐methylphenyl...) Show SMILES COc1cccc2c(Nc3ccc(C)c(F)c3)cc(nc12)C(=O)N1CCCCC1 Show InChI InChI=1S/C23H24FN3O2/c1-15-9-10-16(13-18(15)24)25-19-14-20(23(28)27-11-4-3-5-12-27)26-22-17(19)7-6-8-21(22)29-2/h6-10,13-14H,3-5,11-12H2,1-2H3,(H,25,26)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of California, San Francisco, San Francisco, CA 94143-0521, USA					Assay Description Erythrocyte suspension (100 µL) was added to each well of a 96-well microplate to which test compounds were added. After 15 min incubation, 20 &...				Chem Biol 20: 1235-44 (2013) Article DOI: 10.1016/j.chembiol.2013.08.005 BindingDB Entry DOI: 10.7270/Q22F7M35
					More data for this Ligand-Target Pair
Urea transporter A1 (UT-A1) (Rattus norvegicus (Rat))	BDBM115189 (N‐(3‐fluoro‐4‐methylphenyl...) Show SMILES COc1cccc2c(Nc3ccc(C)c(F)c3)cc(nc12)C(=O)N1CCCCC1 Show InChI InChI=1S/C23H24FN3O2/c1-15-9-10-16(13-18(15)24)25-19-14-20(23(28)27-11-4-3-5-12-27)26-22-17(19)7-6-8-21(22)29-2/h6-10,13-14H,3-5,11-12H2,1-2H3,(H,25,26)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of California, San Francisco, San Francisco, CA 94143-0521, USA					Assay Description The urea concentration dependence of UT-A1 inhibition was studied from inhibitor concentration response data (0.3 - 60 µM) using different of ur...				Chem Biol 20: 1235-44 (2013) Article DOI: 10.1016/j.chembiol.2013.08.005 BindingDB Entry DOI: 10.7270/Q22F7M35
					More data for this Ligand-Target Pair