BDBM115193 (5E)‐5‐[(4‐hydroxy‐3‐methoxyphenyl)methylidene]‐2‐ imino‐1,3‐thiazolidin‐4‐one::UT-A1 inhibitor B4

SMILES: COc1cc(\C=C2\SC(=N)NC2=O)ccc1O

InChI Key: InChIKey=ICKPGBPIOPGQTC-WEVVVXLNSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 115193   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Urea transporter 1 (Rattus norvegicus (Rat))	BDBM115193 ((5E)‐5‐[(4‐hydroxy‐3‐...) Show SMILES COc1cc(\C=C2\SC(=N)NC2=O)ccc1O Show InChI InChI=1S/C11H10N2O3S/c1-16-8-4-6(2-3-7(8)14)5-9-10(15)13-11(12)17-9/h2-5,14H,1H3,(H2,12,13,15)/b9-5+	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of California, San Francisco, San Francisco, CA 94143-0521, USA					Assay Description Erythrocyte suspension (100 µL) was added to each well of a 96-well microplate to which test compounds were added. After 15 min incubation, 20 &...				Chem Biol 20: 1235-44 (2013) Article DOI: 10.1016/j.chembiol.2013.08.005 BindingDB Entry DOI: 10.7270/Q22F7M35
					More data for this Ligand-Target Pair
Urea transporter 2 (Rattus norvegicus (Rat))	BDBM115193 ((5E)‐5‐[(4‐hydroxy‐3‐...) Show SMILES COc1cc(\C=C2\SC(=N)NC2=O)ccc1O Show InChI InChI=1S/C11H10N2O3S/c1-16-8-4-6(2-3-7(8)14)5-9-10(15)13-11(12)17-9/h2-5,14H,1H3,(H2,12,13,15)/b9-5+	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of California, San Francisco, San Francisco, CA 94143-0521, USA					Assay Description The urea concentration dependence of UT-A1 inhibition was studied from inhibitor concentration response data (0.3 - 60 µM) using different of ur...				Chem Biol 20: 1235-44 (2013) Article DOI: 10.1016/j.chembiol.2013.08.005 BindingDB Entry DOI: 10.7270/Q22F7M35
					More data for this Ligand-Target Pair