Found 10 hits for monomerid = 118315 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM118315
![PNG](/data/jpeg/tenK11/BindingDB_118315.png) (US8653092, 83)Show SMILES COc1ncc(cc1C)N1CCc2ncnc(N[C@H]3CCN(C3)C(=O)C3CCOCC3)c2C1 |r| Show InChI InChI=1S/C24H32N6O3/c1-16-11-19(12-25-23(16)32-2)29-8-4-21-20(14-29)22(27-15-26-21)28-18-3-7-30(13-18)24(31)17-5-9-33-10-6-17/h11-12,15,17-18H,3-10,13-14H2,1-2H3,(H,26,27,28)/t18-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 432 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description Test of Lipid Kinase Activity: The kinase reaction is performed in a final volume of 50 μl per well of a half area COSTAR, 96 well plate. The fi... |
US Patent US8653092 (2014)
BindingDB Entry DOI: 10.7270/Q2M61HXZ |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM118315
![PNG](/data/jpeg/tenK11/BindingDB_118315.png) (US8653092, 83)Show SMILES COc1ncc(cc1C)N1CCc2ncnc(N[C@H]3CCN(C3)C(=O)C3CCOCC3)c2C1 |r| Show InChI InChI=1S/C24H32N6O3/c1-16-11-19(12-25-23(16)32-2)29-8-4-21-20(14-29)22(27-15-26-21)28-18-3-7-30(13-18)24(31)17-5-9-33-10-6-17/h11-12,15,17-18H,3-10,13-14H2,1-2H3,(H,26,27,28)/t18-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description Test of Lipid Kinase Activity: The kinase reaction is performed in a final volume of 50 μl per well of a half area COSTAR, 96 well plate. The fi... |
US Patent US8653092 (2014)
BindingDB Entry DOI: 10.7270/Q2M61HXZ |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM118315
![PNG](/data/jpeg/tenK11/BindingDB_118315.png) (US8653092, 83)Show SMILES COc1ncc(cc1C)N1CCc2ncnc(N[C@H]3CCN(C3)C(=O)C3CCOCC3)c2C1 |r| Show InChI InChI=1S/C24H32N6O3/c1-16-11-19(12-25-23(16)32-2)29-8-4-21-20(14-29)22(27-15-26-21)28-18-3-7-30(13-18)24(31)17-5-9-33-10-6-17/h11-12,15,17-18H,3-10,13-14H2,1-2H3,(H,26,27,28)/t18-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.29E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of PI3Kgamma (unknown origin) using phosphatidyl inositol as substrate measured after 30 mins by Alexa Fluor647-labelled ADP tracer based ... |
ACS Med Chem Lett 8: 975-980 (2017)
Article DOI: 10.1021/acsmedchemlett.7b00293 BindingDB Entry DOI: 10.7270/Q2SX6GR0 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM118315
![PNG](/data/jpeg/tenK11/BindingDB_118315.png) (US8653092, 83)Show SMILES COc1ncc(cc1C)N1CCc2ncnc(N[C@H]3CCN(C3)C(=O)C3CCOCC3)c2C1 |r| Show InChI InChI=1S/C24H32N6O3/c1-16-11-19(12-25-23(16)32-2)29-8-4-21-20(14-29)22(27-15-26-21)28-18-3-7-30(13-18)24(31)17-5-9-33-10-6-17/h11-12,15,17-18H,3-10,13-14H2,1-2H3,(H,26,27,28)/t18-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.02E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of recombinant PI3Kbeta (unknown origin) using phosphatidyl inositol/n-Octyl-glucoside as substrate measured after 60 mins by KinaseGlo as... |
ACS Med Chem Lett 8: 975-980 (2017)
Article DOI: 10.1021/acsmedchemlett.7b00293 BindingDB Entry DOI: 10.7270/Q2SX6GR0 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM118315
![PNG](/data/jpeg/tenK11/BindingDB_118315.png) (US8653092, 83)Show SMILES COc1ncc(cc1C)N1CCc2ncnc(N[C@H]3CCN(C3)C(=O)C3CCOCC3)c2C1 |r| Show InChI InChI=1S/C24H32N6O3/c1-16-11-19(12-25-23(16)32-2)29-8-4-21-20(14-29)22(27-15-26-21)28-18-3-7-30(13-18)24(31)17-5-9-33-10-6-17/h11-12,15,17-18H,3-10,13-14H2,1-2H3,(H,26,27,28)/t18-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of PI3Kdelta (unknown origin) using phosphatidyl inositol as substrate measured after 60 mins by Alexa Fluor647-labelled ADP tracer based ... |
ACS Med Chem Lett 8: 975-980 (2017)
Article DOI: 10.1021/acsmedchemlett.7b00293 BindingDB Entry DOI: 10.7270/Q2SX6GR0 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM118315
![PNG](/data/jpeg/tenK11/BindingDB_118315.png) (US8653092, 83)Show SMILES COc1ncc(cc1C)N1CCc2ncnc(N[C@H]3CCN(C3)C(=O)C3CCOCC3)c2C1 |r| Show InChI InChI=1S/C24H32N6O3/c1-16-11-19(12-25-23(16)32-2)29-8-4-21-20(14-29)22(27-15-26-21)28-18-3-7-30(13-18)24(31)17-5-9-33-10-6-17/h11-12,15,17-18H,3-10,13-14H2,1-2H3,(H,26,27,28)/t18-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.19E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of recombinant human myristoylated PI3Kalpha catalytic domain expressed in Rat1 cells assessed as reduction in Akt phosphorylation at Ser4... |
ACS Med Chem Lett 8: 975-980 (2017)
Article DOI: 10.1021/acsmedchemlett.7b00293 BindingDB Entry DOI: 10.7270/Q2SX6GR0 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM118315
![PNG](/data/jpeg/tenK11/BindingDB_118315.png) (US8653092, 83)Show SMILES COc1ncc(cc1C)N1CCc2ncnc(N[C@H]3CCN(C3)C(=O)C3CCOCC3)c2C1 |r| Show InChI InChI=1S/C24H32N6O3/c1-16-11-19(12-25-23(16)32-2)29-8-4-21-20(14-29)22(27-15-26-21)28-18-3-7-30(13-18)24(31)17-5-9-33-10-6-17/h11-12,15,17-18H,3-10,13-14H2,1-2H3,(H,26,27,28)/t18-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9.87E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of recombinant human myristoylated PI3Kbeta catalytic domain expressed in Rat1 cells assessed as reduction in Akt phosphorylation at Ser47... |
ACS Med Chem Lett 8: 975-980 (2017)
Article DOI: 10.1021/acsmedchemlett.7b00293 BindingDB Entry DOI: 10.7270/Q2SX6GR0 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Mus musculus (Mouse)) | BDBM118315
![PNG](/data/jpeg/tenK11/BindingDB_118315.png) (US8653092, 83)Show SMILES COc1ncc(cc1C)N1CCc2ncnc(N[C@H]3CCN(C3)C(=O)C3CCOCC3)c2C1 |r| Show InChI InChI=1S/C24H32N6O3/c1-16-11-19(12-25-23(16)32-2)29-8-4-21-20(14-29)22(27-15-26-21)28-18-3-7-30(13-18)24(31)17-5-9-33-10-6-17/h11-12,15,17-18H,3-10,13-14H2,1-2H3,(H,26,27,28)/t18-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 91 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of PI3Kdelta in Balb/c mouse splenocytes assessed as reduction in anti-IgM stimulated CD86 expression pretreated for 1 hr followed by anti... |
ACS Med Chem Lett 8: 975-980 (2017)
Article DOI: 10.1021/acsmedchemlett.7b00293 BindingDB Entry DOI: 10.7270/Q2SX6GR0 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM118315
![PNG](/data/jpeg/tenK11/BindingDB_118315.png) (US8653092, 83)Show SMILES COc1ncc(cc1C)N1CCc2ncnc(N[C@H]3CCN(C3)C(=O)C3CCOCC3)c2C1 |r| Show InChI InChI=1S/C24H32N6O3/c1-16-11-19(12-25-23(16)32-2)29-8-4-21-20(14-29)22(27-15-26-21)28-18-3-7-30(13-18)24(31)17-5-9-33-10-6-17/h11-12,15,17-18H,3-10,13-14H2,1-2H3,(H,26,27,28)/t18-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 373 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of recombinant human myristoylated PI3Kalpha catalytic domain expressed in Rat1 cells assessed as reduction in Akt phosphorylation at Ser4... |
ACS Med Chem Lett 8: 975-980 (2017)
Article DOI: 10.1021/acsmedchemlett.7b00293 BindingDB Entry DOI: 10.7270/Q2SX6GR0 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM118315
![PNG](/data/jpeg/tenK11/BindingDB_118315.png) (US8653092, 83)Show SMILES COc1ncc(cc1C)N1CCc2ncnc(N[C@H]3CCN(C3)C(=O)C3CCOCC3)c2C1 |r| Show InChI InChI=1S/C24H32N6O3/c1-16-11-19(12-25-23(16)32-2)29-8-4-21-20(14-29)22(27-15-26-21)28-18-3-7-30(13-18)24(31)17-5-9-33-10-6-17/h11-12,15,17-18H,3-10,13-14H2,1-2H3,(H,26,27,28)/t18-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 358 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of recombinant human myristoylated PI3Kdelta catalytic domain expressed in Rat1 cells assessed as reduction in Akt phosphorylation at Ser4... |
ACS Med Chem Lett 8: 975-980 (2017)
Article DOI: 10.1021/acsmedchemlett.7b00293 BindingDB Entry DOI: 10.7270/Q2SX6GR0 |
More data for this Ligand-Target Pair | |