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SMILES: CC(C)(O)C#Cc1ccc2[nH]c(=O)c(-c3cccs3)c(OCC3CCOCC3)c2c1

InChI Key: InChIKey=GTWVBACDIAKLRV-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 119685   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM119685
PNG
(US8680116, 1-57)
Show SMILES CC(C)(O)C#Cc1ccc2[nH]c(=O)c(-c3cccs3)c(OCC3CCOCC3)c2c1
Show InChI InChI=1S/C24H25NO4S/c1-24(2,27)10-7-16-5-6-19-18(14-16)22(29-15-17-8-11-28-12-9-17)21(23(26)25-19)20-4-3-13-30-20/h3-6,13-14,17,27H,8-9,11-12,15H2,1-2H3,(H,25,26)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
 1.80n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...

US Patent US8680116 (2014)


BindingDB Entry DOI: 10.7270/Q2N29VM1
More data for this
Ligand-Target Pair