BDBM120583 US8703768, 183

SMILES: Cc1ccc(NC(=O)c2nc(cnc2Nc2cncnc2)C2CC2)c(n1)C(=O)NCC(C)(C)O

InChI Key: InChIKey=HDPHUHBOZIMVIG-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 120583   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM120583 (US8703768, 183) Show SMILES Cc1ccc(NC(=O)c2nc(cnc2Nc2cncnc2)C2CC2)c(n1)C(=O)NCC(C)(C)O Show InChI InChI=1S/C23H26N8O3/c1-13-4-7-16(18(28-13)21(32)27-11-23(2,3)34)31-22(33)19-20(29-15-8-24-12-25-9-15)26-10-17(30-19)14-5-6-14/h4,7-10,12,14,34H,5-6,11H2,1-3H3,(H,26,29)(H,27,32)(H,31,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description PDE10 activity of the compounds of the present invention was determined using a Scintillation Proximity Assay (SPA)-based method similar to the one p...				US Patent US8703768 (2014) BindingDB Entry DOI: 10.7270/Q27P8X37
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