BDBM120615 US8703768, 216

SMILES: CNC(=O)c1cc(OCCO)ccc1NC(=O)c1nc(cnc1Nc1cncnc1)C1CC1

InChI Key: InChIKey=WMEYAVUXORDJQN-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 120615   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM120615 (US8703768, 216) Show SMILES CNC(=O)c1cc(OCCO)ccc1NC(=O)c1nc(cnc1Nc1cncnc1)C1CC1 Show InChI InChI=1S/C22H23N7O4/c1-23-21(31)16-8-15(33-7-6-30)4-5-17(16)29-22(32)19-20(27-14-9-24-12-25-10-14)26-11-18(28-19)13-2-3-13/h4-5,8-13,30H,2-3,6-7H2,1H3,(H,23,31)(H,26,27)(H,29,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description PDE10 activity of the compounds of the present invention was determined using a Scintillation Proximity Assay (SPA)-based method similar to the one p...				US Patent US8703768 (2014) BindingDB Entry DOI: 10.7270/Q27P8X37
					More data for this Ligand-Target Pair