BDBM120674 US8703768, 275
SMILES: CC1(COC1)NC(=O)c1ncccc1NC(=O)c1nc(cnc1Nc1cncnc1)C1CC1
InChI Key: InChIKey=ABELAFVBUKBPTB-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human)) | BDBM120674 (US8703768, 275) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc. US Patent | Assay Description PDE10 activity of the compounds of the present invention was determined using a Scintillation Proximity Assay (SPA)-based method similar to the one p... | US Patent US8703768 (2014) BindingDB Entry DOI: 10.7270/Q27P8X37 | |||||||||||
More data for this Ligand-Target Pair |