BDBM120687 US8703768, 288

SMILES: CNC(=O)c1cc(F)c(F)cc1NC(=O)c1nc(cnc1Nc1cncnc1)C1CC1

InChI Key: InChIKey=VVMYOXNSPRHQOU-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 120687   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM120687 (US8703768, 288) Show SMILES CNC(=O)c1cc(F)c(F)cc1NC(=O)c1nc(cnc1Nc1cncnc1)C1CC1 Show InChI InChI=1S/C20H17F2N7O2/c1-23-19(30)12-4-13(21)14(22)5-15(12)29-20(31)17-18(27-11-6-24-9-25-7-11)26-8-16(28-17)10-2-3-10/h4-10H,2-3H2,1H3,(H,23,30)(H,26,27)(H,29,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description PDE10 activity of the compounds of the present invention was determined using a Scintillation Proximity Assay (SPA)-based method similar to the one p...				US Patent US8703768 (2014) BindingDB Entry DOI: 10.7270/Q27P8X37
					More data for this Ligand-Target Pair