BDBM120734 US8703768, 335

SMILES: Cn1ncc(NC(=O)c2nc(cnc2Nc2cncnc2)C2CC2)c1C(=O)N1CCCO1

InChI Key: InChIKey=QTTKVJJYXLZWQW-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 120734   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM120734 (US8703768, 335) Show SMILES Cn1ncc(NC(=O)c2nc(cnc2Nc2cncnc2)C2CC2)c1C(=O)N1CCCO1 Show InChI InChI=1S/C20H21N9O3/c1-28-17(20(31)29-5-2-6-32-29)15(10-24-28)27-19(30)16-18(25-13-7-21-11-22-8-13)23-9-14(26-16)12-3-4-12/h7-12H,2-6H2,1H3,(H,23,25)(H,27,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description PDE10 activity of the compounds of the present invention was determined using a Scintillation Proximity Assay (SPA)-based method similar to the one p...				US Patent US8703768 (2014) BindingDB Entry DOI: 10.7270/Q27P8X37
					More data for this Ligand-Target Pair