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SMILES: COc1ccc(c(OC)c1)-c1ccnc(NC2CCc3ccc(cc3C2)C(=O)NO)n1

InChI Key: InChIKey=DWASHNRPGLJXQF-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 120961   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Histone deacetylase 8


(Homo sapiens (Human))		BDBM120961
PNG
(US8716285, 18)
Show SMILES COc1ccc(c(OC)c1)-c1ccnc(NC2CCc3ccc(cc3C2)C(=O)NO)n1
Show InChI InChI=1S/C23H24N4O4/c1-30-18-7-8-19(21(13-18)31-2)20-9-10-24-23(26-20)25-17-6-5-14-3-4-15(22(28)27-29)11-16(14)12-17/h3-4,7-11,13,17,29H,5-6,12H2,1-2H3,(H,27,28)(H,24,25,26)
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KEGG

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Similars
US Patent
n/an/a 1.23E+3n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Compounds were tested for their ability to inhibit histone deacetylase 8 using an in vitro deacetylation assay. In a detailed procedure, 8 μl o...

US Patent US8716285 (2014)


BindingDB Entry DOI: 10.7270/Q2K072XG
More data for this
Ligand-Target Pair