BDBM121008 US8716285, 65

SMILES: CN1CC(Cc2cc(ccc12)C(=O)NO)NS(=O)(=O)c1ccc(Cl)cc1

InChI Key: InChIKey=DGLALNDMQZJOFK-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 121008   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone deacetylase 8 (Homo sapiens (Human))	BDBM121008 (US8716285, 65) Show SMILES CN1CC(Cc2cc(ccc12)C(=O)NO)NS(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C17H18ClN3O4S/c1-21-10-14(20-26(24,25)15-5-3-13(18)4-6-15)9-12-8-11(17(22)19-23)2-7-16(12)21/h2-8,14,20,23H,9-10H2,1H3,(H,19,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	750	n/a	n/a	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description Compounds were tested for their ability to inhibit histone deacetylase 8 using an in vitro deacetylation assay. In a detailed procedure, 8 μl o...				US Patent US8716285 (2014) BindingDB Entry DOI: 10.7270/Q2K072XG
					More data for this Ligand-Target Pair