BDBM123352 US8742106, 1.73

SMILES: CC(Oc1cc(c2c(nn(C)c2n1)-c1ccccc1)C(F)(F)F)C(=O)N[C@@H](C)c1ccccc1

InChI Key: InChIKey=GBWJJRMQQJCNOS-VYRBHSGPSA-N

Data: 2 Kd

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 123352   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Orexin receptor type 2 (Homo sapiens (Human))	BDBM123352 (US8742106, 1.73) Show SMILES CC(Oc1cc(c2c(nn(C)c2n1)-c1ccccc1)C(F)(F)F)C(=O)N[C@@H](C)c1ccccc1 |r| Show InChI InChI=1S/C25H23F3N4O2/c1-15(17-10-6-4-7-11-17)29-24(33)16(2)34-20-14-19(25(26,27)28)21-22(18-12-8-5-9-13-18)31-32(3)23(21)30-20/h4-16H,1-3H3,(H,29,33)/t15-,16?/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	n/a	162	n/a	n/a	n/a	7.5	4
Novartis AG US Patent					Assay Description For crude cell membrane preparations, cells (CHO, Chinese hamster ovary or HEK, human embryonic kidney) expressing human orexin 1 or human orexin 2 r...				US Patent US8742106 (2014) BindingDB Entry DOI: 10.7270/Q22V2DSW
					More data for this Ligand-Target Pair
Orexin receptor type 1 (Homo sapiens (Human))	BDBM123352 (US8742106, 1.73) Show SMILES CC(Oc1cc(c2c(nn(C)c2n1)-c1ccccc1)C(F)(F)F)C(=O)N[C@@H](C)c1ccccc1 |r| Show InChI InChI=1S/C25H23F3N4O2/c1-15(17-10-6-4-7-11-17)29-24(33)16(2)34-20-14-19(25(26,27)28)21-22(18-12-8-5-9-13-18)31-32(3)23(21)30-20/h4-16H,1-3H3,(H,29,33)/t15-,16?/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	n/a	225	n/a	n/a	n/a	7.5	4
Novartis AG US Patent					Assay Description For crude cell membrane preparations, cells (CHO, Chinese hamster ovary or HEK, human embryonic kidney) expressing human orexin 1 or human orexin 2 r...				US Patent US8742106 (2014) BindingDB Entry DOI: 10.7270/Q22V2DSW
					More data for this Ligand-Target Pair