BDBM123908 US8754113, I-3-56

SMILES: Clc1ccc(s1)-c1ccc2nc(Cc3nnc(CC(=O)NC4(CC4)C#N)o3)sc2c1

InChI Key: InChIKey=CLEKXRTUWQTFLM-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 123908   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Endothelial lipase (Homo sapiens (Human))	BDBM123908 (US8754113, I-3-56) Show SMILES Clc1ccc(s1)-c1ccc2nc(Cc3nnc(CC(=O)NC4(CC4)C#N)o3)sc2c1 Show InChI InChI=1S/C20H14ClN5O2S2/c21-15-4-3-13(29-15)11-1-2-12-14(7-11)30-19(23-12)9-18-26-25-17(28-18)8-16(27)24-20(10-22)5-6-20/h1-4,7H,5-6,8-9H2,(H,24,27)	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	37
Shionogi & Co., Ltd. US Patent					Assay Description After the present compound dissolved in DMSO was added to become 0.5% DMSO to the reaction buffer consisting of 20 mM tris hydrochloric acid (pH7.4),...				US Patent US8754113 (2014) BindingDB Entry DOI: 10.7270/Q27D2SVD
					More data for this Ligand-Target Pair