BDBM124412 US8759532, 65

SMILES: O=C(NC1(Cc2ccccc2)CC1)c1cccnc1Oc1ccc(cc1)C(=O)c1nc2ccccc2[nH]1

InChI Key: InChIKey=PDYKWUPDGJLWQK-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 124412   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM124412 (US8759532, 65) Show SMILES O=C(NC1(Cc2ccccc2)CC1)c1cccnc1Oc1ccc(cc1)C(=O)c1nc2ccccc2[nH]1 Show InChI InChI=1S/C30H24N4O3/c35-26(27-32-24-10-4-5-11-25(24)33-27)21-12-14-22(15-13-21)37-29-23(9-6-18-31-29)28(36)34-30(16-17-30)19-20-7-2-1-3-8-20/h1-15,18H,16-17,19H2,(H,32,33)(H,34,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.168	n/a	n/a	n/a	n/a	n/a	25
Amgen Inc. US Patent					Assay Description To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die...				US Patent US8759532 (2014) BindingDB Entry DOI: 10.7270/Q25D8QHR
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