BDBM124458 US8759532, 124

SMILES: CC(=O)N1CCC(CC1)c1cccnc1Oc1ccc(Nc2nc3ccccc3s2)cc1

InChI Key: InChIKey=OBECUGBNTGJTQH-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 124458   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM124458 (US8759532, 124) Show SMILES CC(=O)N1CCC(CC1)c1cccnc1Oc1ccc(Nc2nc3ccccc3s2)cc1 Show InChI InChI=1S/C25H24N4O2S/c1-17(30)29-15-12-18(13-16-29)21-5-4-14-26-24(21)31-20-10-8-19(9-11-20)27-25-28-22-6-2-3-7-23(22)32-25/h2-11,14,18H,12-13,15-16H2,1H3,(H,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.175	n/a	n/a	n/a	n/a	n/a	25
Amgen Inc. US Patent					Assay Description To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die...				US Patent US8759532 (2014) BindingDB Entry DOI: 10.7270/Q25D8QHR
					More data for this Ligand-Target Pair