BDBM124476 US8759532, 146

SMILES: C[C@H](Cc1ccc(F)cc1)NC(=O)c1cccnc1Oc1ccc(cc1)C(=O)c1nc2ccccc2[nH]1

InChI Key: InChIKey=FOSHITYJKMWOLO-GOSISDBHSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 124476   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM124476 (US8759532, 146) Show SMILES C[C@H](Cc1ccc(F)cc1)NC(=O)c1cccnc1Oc1ccc(cc1)C(=O)c1nc2ccccc2[nH]1 |r| Show InChI InChI=1S/C29H23FN4O3/c1-18(17-19-8-12-21(30)13-9-19)32-28(36)23-5-4-16-31-29(23)37-22-14-10-20(11-15-22)26(35)27-33-24-6-2-3-7-25(24)34-27/h2-16,18H,17H2,1H3,(H,32,36)(H,33,34)/t18-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.135	n/a	n/a	n/a	n/a	n/a	25
Amgen Inc. US Patent					Assay Description To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die...				US Patent US8759532 (2014) BindingDB Entry DOI: 10.7270/Q25D8QHR
					More data for this Ligand-Target Pair