BDBM124496 US8759532, 170

SMILES: CC(=O)N1CCC[C@H](C1)c1cccnc1Oc1ccc(Nc2nc3ccccc3s2)cc1

InChI Key: InChIKey=LFECZISJRXSOHN-GOSISDBHSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 124496   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM124496 (US8759532, 170) Show SMILES CC(=O)N1CCC[C@H](C1)c1cccnc1Oc1ccc(Nc2nc3ccccc3s2)cc1 |r| Show InChI InChI=1S/C25H24N4O2S/c1-17(30)29-15-5-6-18(16-29)21-7-4-14-26-24(21)31-20-12-10-19(11-13-20)27-25-28-22-8-2-3-9-23(22)32-25/h2-4,7-14,18H,5-6,15-16H2,1H3,(H,27,28)/t18-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.268	n/a	n/a	n/a	n/a	n/a	25
Amgen Inc. US Patent					Assay Description To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die...				US Patent US8759532 (2014) BindingDB Entry DOI: 10.7270/Q25D8QHR
					More data for this Ligand-Target Pair