BDBM124521 US8759532, 198

SMILES: O=C1CCC(CC1)c1cccnc1Oc1ccc(Nc2nc3ccccc3s2)cc1

InChI Key: InChIKey=CSUBZUSRIRAQML-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 124521   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM124521 (US8759532, 198) Show SMILES O=C1CCC(CC1)c1cccnc1Oc1ccc(Nc2nc3ccccc3s2)cc1 Show InChI InChI=1S/C24H21N3O2S/c28-18-11-7-16(8-12-18)20-4-3-15-25-23(20)29-19-13-9-17(10-14-19)26-24-27-21-5-1-2-6-22(21)30-24/h1-6,9-10,13-16H,7-8,11-12H2,(H,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.123	n/a	n/a	n/a	n/a	n/a	25
Amgen Inc. US Patent					Assay Description To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die...				US Patent US8759532 (2014) BindingDB Entry DOI: 10.7270/Q25D8QHR
					More data for this Ligand-Target Pair