BDBM124559 US8759532, 240
SMILES: O=C(c1nc2ccccc2[nH]1)c1ccc(Oc2ncccc2C2CCCC(=O)CC2)cc1
InChI Key: InChIKey=PTUZHKGYWLATFH-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human)) | BDBM124559![]() (US8759532, 240) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.0770 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc. US Patent | Assay Description To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die... | US Patent US8759532 (2014) BindingDB Entry DOI: 10.7270/Q25D8QHR | |||||||||||
More data for this Ligand-Target Pair |