BDBM126002 US8772288, 73

SMILES: Cc1nnc(o1)-c1ccc(C)c(c1)-c1ccc2c(NC(=O)C22CCC(O)CC2)c1

InChI Key: InChIKey=JCJPTNWSXJYHNK-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 126002   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM126002 (US8772288, 73) Show SMILES Cc1nnc(o1)-c1ccc(C)c(c1)-c1ccc2c(NC(=O)C22CCC(O)CC2)c1 |(3.72,7.91,;2.95,6.58,;3.85,5.33,;2.95,4.09,;1.48,4.56,;1.48,6.1,;.15,3.79,;-1.18,4.56,;-2.52,3.79,;-2.52,2.25,;-3.85,1.48,;-1.18,1.48,;.15,2.25,;-1.18,-.06,;.15,-.83,;.15,-2.37,;-1.18,-3.14,;-2.52,-2.37,;-3.66,-3.4,;-3.04,-4.81,;-3.81,-6.14,;-1.51,-4.64,;-1.9,-6.13,;-.81,-7.22,;.67,-6.82,;1.76,-7.91,;1.07,-5.33,;-.02,-4.25,;-2.52,-.83,)| Show InChI InChI=1S/C23H23N3O3/c1-13-3-4-16(21-26-25-14(2)29-21)11-18(13)15-5-6-19-20(12-15)24-22(28)23(19)9-7-17(27)8-10-23/h3-6,11-12,17,27H,7-10H2,1-2H3,(H,24,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.70	n/a	n/a	n/a	n/a	7.5	25
Almirall, S.A. US Patent					Assay Description Enzymatic activity assay was performed in 96-well microtiter plates (Corning, catalog number #3686) using a total volume of 50 ul of an assay buffer ...				US Patent US8772288 (2014) BindingDB Entry DOI: 10.7270/Q2T152BM
					More data for this Ligand-Target Pair