BDBM12706 4-amino-3-cyano-N-[2-fluoro-4-(2-methanesulfonylphenyl)phenyl]-1-(4-methoxyphenyl)-1H-pyrazole-5-carboxamide::N-arylpyrazole carboxamide 12
SMILES: COc1ccc(cc1)-n1nc(C#N)c(N)c1C(=O)Nc1ccc(cc1F)-c1ccccc1S(C)(=O)=O
InChI Key: InChIKey=YEICLSYLHFPMDT-UHFFFAOYSA-N
Data: 1 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Coagulation factor X (Homo sapiens (Human)) | BDBM12706 (4-amino-3-cyano-N-[2-fluoro-4-(2-methanesulfonylph...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 8.40 | -10.9 | n/a | n/a | n/a | n/a | n/a | 7.0 | 22 |
Bristol-Myers Squibb Company | Assay Description Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter... | Bioorg Med Chem Lett 16: 3755-60 (2006) Article DOI: 10.1016/j.bmcl.2006.04.044 BindingDB Entry DOI: 10.7270/Q2319T41 | |||||||||||
More data for this Ligand-Target Pair |