BDBM127315 US8791268, 26

SMILES: CC(C(=O)NCc1ccc(nc1N1CCC(C)CC1)C(F)(F)F)c1cc(F)c(N)c(F)c1

InChI Key: InChIKey=KOJARYJLVZXXMB-UHFFFAOYSA-N

Data: 3 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 127315   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vanilloid receptor (Rattus norvegicus (rat))	BDBM127315 (US8791268, 26) Show SMILES CC(C(=O)NCc1ccc(nc1N1CCC(C)CC1)C(F)(F)F)c1cc(F)c(N)c(F)c1 Show InChI InChI=1S/C22H25F5N4O/c1-12-5-7-31(8-6-12)20-14(3-4-18(30-20)22(25,26)27)11-29-21(32)13(2)15-9-16(23)19(28)17(24)10-15/h3-4,9-10,12-13H,5-8,11,28H2,1-2H3,(H,29,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	3.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Gruenenthal GmbH US Patent					Assay Description The FLIPR protocol consists of two substance additions. Initially, the compounds to be tested (10 uM) are pipeted onto the cells and the Ca2+ influx ...				US Patent US8791268 (2014) BindingDB Entry DOI: 10.7270/Q2BV7F9D
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM127315 (US8791268, 26) Show SMILES CC(C(=O)NCc1ccc(nc1N1CCC(C)CC1)C(F)(F)F)c1cc(F)c(N)c(F)c1 Show InChI InChI=1S/C22H25F5N4O/c1-12-5-7-31(8-6-12)20-14(3-4-18(30-20)22(25,26)27)11-29-21(32)13(2)15-9-16(23)19(28)17(24)10-15/h3-4,9-10,12-13H,5-8,11,28H2,1-2H3,(H,29,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	9.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Seoul National University Curated by ChEMBL					Assay Description Antagonist activity at human TRPV1 expressed in CHOK1 cells assessed as reduction in capsaicin-induced intracellular calcium level preincubated for 6...				Bioorg Med Chem 26: 4509-4517 (2018) Article DOI: 10.1016/j.bmc.2018.07.040 BindingDB Entry DOI: 10.7270/Q2348P1P
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM127315 (US8791268, 26) Show SMILES CC(C(=O)NCc1ccc(nc1N1CCC(C)CC1)C(F)(F)F)c1cc(F)c(N)c(F)c1 Show InChI InChI=1S/C22H25F5N4O/c1-12-5-7-31(8-6-12)20-14(3-4-18(30-20)22(25,26)27)11-29-21(32)13(2)15-9-16(23)19(28)17(24)10-15/h3-4,9-10,12-13H,5-8,11,28H2,1-2H3,(H,29,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	9.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Gruenenthal GmbH US Patent					Assay Description The FLIPR protocol consists of two substance additions. Initially, the compounds to be tested (10 uM) are pipeted onto the cells and the Ca2+ influx ...				US Patent US8791268 (2014) BindingDB Entry DOI: 10.7270/Q2BV7F9D
					More data for this Ligand-Target Pair