null

SMILES: COc1ncc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)Nc3cc(n[nH]3)C3CC3)c2n1

InChI Key: InChIKey=HRXHRVGEOCMYJD-GOSISDBHSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 127869   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM127869 (US10251889, Example 242 | US10758542, Example 242 ...) Show SMILES COc1ncc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)Nc3cc(n[nH]3)C3CC3)c2n1 |r| Show InChI InChI=1S/C23H23FN8O2/c1-34-23-15(9-14(24)11-25-23)18-3-2-7-31(18)20-6-8-32-21(28-20)16(12-26-32)22(33)27-19-10-17(29-30-19)13-4-5-13/h6,8-13,18H,2-5,7H2,1H3,(H2,27,29,30,33)/t18-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8.90	n/a	n/a	n/a	n/a	7.5	n/a
Array Biopharma, Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US8791123 (2014) BindingDB Entry DOI: 10.7270/Q2Q23XX7
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM127869 (US10251889, Example 242 | US10758542, Example 242 ...) Show SMILES COc1ncc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)Nc3cc(n[nH]3)C3CC3)c2n1 |r| Show InChI InChI=1S/C23H23FN8O2/c1-34-23-15(9-14(24)11-25-23)18-3-2-7-31(18)20-6-8-32-21(28-20)16(12-26-32)22(33)27-19-10-17(29-30-19)13-4-5-13/h6,8-13,18H,2-5,7H2,1H3,(H2,27,29,30,33)/t18-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8.90	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US9782415 (2017) BindingDB Entry DOI: 10.7270/Q2P84F0G
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM127869 (US10251889, Example 242 | US10758542, Example 242 ...) Show SMILES COc1ncc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)Nc3cc(n[nH]3)C3CC3)c2n1 |r| Show InChI InChI=1S/C23H23FN8O2/c1-34-23-15(9-14(24)11-25-23)18-3-2-7-31(18)20-6-8-32-21(28-20)16(12-26-32)22(33)27-19-10-17(29-30-19)13-4-5-13/h6,8-13,18H,2-5,7H2,1H3,(H2,27,29,30,33)/t18-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8.90	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US10758542 (2020) BindingDB Entry DOI: 10.7270/Q2RB77PD
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM127869 (US10251889, Example 242 | US10758542, Example 242 ...) Show SMILES COc1ncc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)Nc3cc(n[nH]3)C3CC3)c2n1 |r| Show InChI InChI=1S/C23H23FN8O2/c1-34-23-15(9-14(24)11-25-23)18-3-2-7-31(18)20-6-8-32-21(28-20)16(12-26-32)22(33)27-19-10-17(29-30-19)13-4-5-13/h6,8-13,18H,2-5,7H2,1H3,(H2,27,29,30,33)/t18-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8.90	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description Trk enzymatic selectivity was assessed using Omnia™ Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) an...				US Patent US9796724 (2017) BindingDB Entry DOI: 10.7270/Q27M0B21
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM127869 (US10251889, Example 242 | US10758542, Example 242 ...) Show SMILES COc1ncc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)Nc3cc(n[nH]3)C3CC3)c2n1 |r| Show InChI InChI=1S/C23H23FN8O2/c1-34-23-15(9-14(24)11-25-23)18-3-2-7-31(18)20-6-8-32-21(28-20)16(12-26-32)22(33)27-19-10-17(29-30-19)13-4-5-13/h6,8-13,18H,2-5,7H2,1H3,(H2,27,29,30,33)/t18-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8.90	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2R49T22
					More data for this Ligand-Target Pair