BDBM127972 US8796310, 14C

SMILES: Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1cnc(s1)[C@@]1(O)CCCc2c(cccc12)C(O)=O

InChI Key: InChIKey=OCQAZEACLVLCPN-RUZDIDTESA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 127972   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM127972 (US8796310, 14C) Show SMILES Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1cnc(s1)[C@@]1(O)CCCc2c(cccc12)C(O)=O Show InChI InChI=1S/C26H21F3N4O3S/c1-14-10-19(32-22(11-14)33-21-12-15(7-9-30-21)26(27,28)29)20-13-31-24(37-20)25(36)8-3-5-16-17(23(34)35)4-2-6-18(16)25/h2,4,6-7,9-13,36H,3,5,8H2,1H3,(H,34,35)(H,30,32,33)/t25-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<0.5	n/a	n/a	n/a	n/a	7.5	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Cama Bio...				US Patent US8796310 (2014) BindingDB Entry DOI: 10.7270/Q29W0D61
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