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SMILES: CONC(=O)c1ccc2c(CCC[C@]2(O)c2ncc(s2)-c2cc(C)cc(Nc3cc(ccn3)C(F)(F)F)n2)c1

InChI Key: InChIKey=MLBVUHDKFGVEEM-AREMUKBSSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 127999   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM127999
PNG
(US8796310, 22F)
Show SMILES CONC(=O)c1ccc2c(CCC[C@]2(O)c2ncc(s2)-c2cc(C)cc(Nc3cc(ccn3)C(F)(F)F)n2)c1
Show InChI InChI=1S/C27H24F3N5O3S/c1-15-10-20(33-23(11-15)34-22-13-18(7-9-31-22)27(28,29)30)21-14-32-25(39-21)26(37)8-3-4-16-12-17(5-6-19(16)26)24(36)35-38-2/h5-7,9-14,37H,3-4,8H2,1-2H3,(H,35,36)(H,31,33,34)/t26-/m1/s1
PDB
MMDB

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Similars

US Patent
n/an/a 0.740n/an/an/an/a7.5n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Cama Bio...


US Patent US8796310 (2014)


BindingDB Entry DOI: 10.7270/Q29W0D61
More data for this
Ligand-Target Pair