BDBM128010 US8796310, 29B

SMILES: COc1ccnc(Nc2cc(C)cc(n2)-c2cnc(s2)[C@]2(O)CCCc3cc(ccc23)C(O)=O)c1

InChI Key: InChIKey=PLNKGQHICRZXGJ-SANMLTNESA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 128010   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM128010 (US8796310, 29B) Show SMILES COc1ccnc(Nc2cc(C)cc(n2)-c2cnc(s2)[C@]2(O)CCCc3cc(ccc23)C(O)=O)c1 Show InChI InChI=1S/C26H24N4O4S/c1-15-10-20(29-23(11-15)30-22-13-18(34-2)7-9-27-22)21-14-28-25(35-21)26(33)8-3-4-16-12-17(24(31)32)5-6-19(16)26/h5-7,9-14,33H,3-4,8H2,1-2H3,(H,31,32)(H,27,29,30)/t26-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	7.5	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Cama Bio...				US Patent US8796310 (2014) BindingDB Entry DOI: 10.7270/Q29W0D61
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