null

SMILES: CC(C)(C)OC(=O)N1CCc2nc(sc2C1)-c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1

InChI Key: InChIKey=XCAGIHJCPNUGAK-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 128475   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM128475 (US8796244, 54) Show SMILES CC(C)(C)OC(=O)N1CCc2nc(sc2C1)-c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1 Show InChI InChI=1S/C27H27F3N6O3S/c1-26(2,3)39-25(38)35-9-8-19-21(14-35)40-23(34-19)17-7-10-36-20(13-31-22(36)12-17)16-5-4-6-18(11-16)33-24(37)32-15-27(28,29)30/h4-7,10-13H,8-9,14-15H2,1-3H3,(H2,32,33,37)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	18.2	n/a	n/a	n/a	n/a	8.0	25
Astex Therapeutics Ltd US Patent					Assay Description VEGFR2 (from Upstate), prepared at 2x final concentration, was incubated with test compounds, biotinylated Flt3 substrate (biotin-VASSDNEYFYVDF) (Cel...				US Patent US8796244 (2014) BindingDB Entry DOI: 10.7270/Q20C4TFP
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM128475 (US8796244, 54) Show SMILES CC(C)(C)OC(=O)N1CCc2nc(sc2C1)-c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1 Show InChI InChI=1S/C27H27F3N6O3S/c1-26(2,3)39-25(38)35-9-8-19-21(14-35)40-23(34-19)17-7-10-36-20(13-31-22(36)12-17)16-5-4-6-18(11-16)33-24(37)32-15-27(28,29)30/h4-7,10-13H,8-9,14-15H2,1-3H3,(H2,32,33,37)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.25	n/a	n/a	n/a	n/a	8.0	25
Astex Therapeutics Ltd US Patent					Assay Description Enzymes (from Upstate) were prepared at 2× final concentration in 1× kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...				US Patent US8796244 (2014) BindingDB Entry DOI: 10.7270/Q20C4TFP
					More data for this Ligand-Target Pair