BDBM128503 US8796244, 82
SMILES: FC(F)(F)CNC(=O)Nc1cccc(c1)-c1cnc2cc(ccn12)-c1ccc(nn1)N1CCC1
InChI Key: InChIKey=DLAWFXCKIUSOJX-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human)) | BDBM128503 (US8796244, 82) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 12.5 | n/a | n/a | n/a | n/a | 8.0 | 25 |
Astex Therapeutics Ltd US Patent | Assay Description VEGFR2 (from Upstate), prepared at 2x final concentration, was incubated with test compounds, biotinylated Flt3 substrate (biotin-VASSDNEYFYVDF) (Cel... | US Patent US8796244 (2014) BindingDB Entry DOI: 10.7270/Q20C4TFP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Fibroblast growth factor receptor 3 (Homo sapiens (Human)) | BDBM128503 (US8796244, 82) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.715 | n/a | n/a | n/a | n/a | 8.0 | 25 |
Astex Therapeutics Ltd US Patent | Assay Description Enzymes (from Upstate) were prepared at 2× final concentration in 1× kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ... | US Patent US8796244 (2014) BindingDB Entry DOI: 10.7270/Q20C4TFP | |||||||||||
More data for this Ligand-Target Pair |