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SMILES: COc1cc2ncc3n(C)nc(-c4ccc(cc4)C#N)c3c2cc1OC(C(N)=O)c1ccc(F)cc1

InChI Key: InChIKey=PRKCPLSMIDYHHS-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 128750   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))		BDBM128750
PNG
(US8802712, 8)
Show SMILES COc1cc2ncc3n(C)nc(-c4ccc(cc4)C#N)c3c2cc1OC(C(N)=O)c1ccc(F)cc1
Show InChI InChI=1S/C27H20FN5O3/c1-33-21-14-31-20-12-22(35-2)23(36-26(27(30)34)17-7-9-18(28)10-8-17)11-19(20)24(21)25(32-33)16-5-3-15(13-29)4-6-16/h3-12,14,26H,1-2H3,(H2,30,34)
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Similars
US Patent
n/an/a<100n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...

US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair