BDBM129890 US8815926, 171::US8815926, 174

SMILES: COc1cnc(nc1-c1nc2C(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1)c1cccc(Cl)c1F)N(C)C

InChI Key: InChIKey=LXBXYZLFDBLELV-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 129890   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MDM2-MDMX (Homo sapiens (Human))	BDBM129890 (US8815926, 171 | US8815926, 174) Show SMILES COc1cnc(nc1-c1nc2C(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1)c1cccc(Cl)c1F)N(C)C Show InChI InChI=1S/C27H25Cl2FN6O2/c1-14(2)35-24-22(32-25(35)21-19(38-5)13-31-27(33-21)34(3)4)26(37)36(18-8-6-7-17(29)20(18)30)23(24)15-9-11-16(28)12-10-15/h6-14,23H,1-5H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.110	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...				US Patent US8815926 (2014) BindingDB Entry DOI: 10.7270/Q29P309G
					More data for this Ligand-Target Pair
MDM2-MDMX (Homo sapiens (Human))	BDBM129890 (US8815926, 171 | US8815926, 174) Show SMILES COc1cnc(nc1-c1nc2C(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1)c1cccc(Cl)c1F)N(C)C Show InChI InChI=1S/C27H25Cl2FN6O2/c1-14(2)35-24-22(32-25(35)21-19(38-5)13-31-27(33-21)34(3)4)26(37)36(18-8-6-7-17(29)20(18)30)23(24)15-9-11-16(28)12-10-15/h6-14,23H,1-5H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.520	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...				US Patent US8815926 (2014) BindingDB Entry DOI: 10.7270/Q29P309G
					More data for this Ligand-Target Pair