BDBM129924 US8815926, 205

SMILES: COc1nc(N)ncc1-c1nc2C(=O)N([C@H](c2n1C(C)C)c1ccc(Cl)cc1)c1cc(Cl)ccc1C

InChI Key: InChIKey=CYGATABVHKQRES-NRFANRHFSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 129924   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MDM2-MDMX (Homo sapiens (Human))	BDBM129924 (US8815926, 205) Show SMILES COc1nc(N)ncc1-c1nc2C(=O)N([C@H](c2n1C(C)C)c1ccc(Cl)cc1)c1cc(Cl)ccc1C |r| Show InChI InChI=1S/C26H24Cl2N6O2/c1-13(2)33-22-20(31-23(33)18-12-30-26(29)32-24(18)36-4)25(35)34(19-11-17(28)8-5-14(19)3)21(22)15-6-9-16(27)10-7-15/h5-13,21H,1-4H3,(H2,29,30,32)/t21-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.110	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...				US Patent US8815926 (2014) BindingDB Entry DOI: 10.7270/Q29P309G
					More data for this Ligand-Target Pair