BDBM130074 US8815901, 85

SMILES: COc1cc(OC)c(Cl)c(c1Cl)-c1ccc(C(=O)Nc2ncc[nH]2)c2ncc(nc12)N(C)CCN(C)C

InChI Key: InChIKey=RMRAUVAJOMBYOP-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 130074   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM130074 (US8815901, 85) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc(C(=O)Nc2ncc[nH]2)c2ncc(nc12)N(C)CCN(C)C |(5.42,6,;6.19,4.67,;5.42,3.33,;6.19,2,;5.42,.67,;6.19,-.67,;7.73,-.67,;3.88,.67,;3.11,-.67,;3.11,2,;3.88,3.33,;3.11,4.67,;1.57,2,;.8,3.33,;-.74,3.33,;-1.51,2,;-3.05,2,;-3.82,3.33,;-3.82,.67,;-5.36,.67,;-6.27,1.91,;-7.73,1.44,;-7.73,-.1,;-6.27,-.58,;-.74,.67,;-1.51,-.67,;-.74,-2,;.8,-2,;1.57,-.67,;.8,.67,;1.57,-3.33,;.8,-4.67,;3.11,-3.33,;3.88,-4.67,;5.42,-4.67,;6.19,-6,;6.19,-3.33,)| Show InChI InChI=1S/C25H27Cl2N7O3/c1-33(2)10-11-34(3)18-13-30-22-15(24(35)32-25-28-8-9-29-25)7-6-14(23(22)31-18)19-20(26)16(36-4)12-17(37-5)21(19)27/h6-9,12-13H,10-11H2,1-5H3,(H2,28,29,32,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	210	n/a	n/a	n/a	n/a	n/a	25
Novartis AG US Patent					Assay Description The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ...				US Patent US8815901 (2014) BindingDB Entry DOI: 10.7270/Q2XG9PT8
					More data for this Ligand-Target Pair