null

SMILES: CN1CC(C1)(C(=O)N1C[C@@H](C[C@H]1C(=O)NC1(CC1)C#N)S(=O)(=O)c1ccccc1Cl)c1ncc(Br)cc1F

InChI Key: InChIKey=MZKPXTUNCMRSJY-APWZRJJASA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 130414   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Procathepsin L (Homo sapiens (Human))	BDBM130414 (US8822505, 14 | US8822505, 16) Show SMILES CN1CC(C1)(C(=O)N1C[C@@H](C[C@H]1C(=O)NC1(CC1)C#N)S(=O)(=O)c1ccccc1Cl)c1ncc(Br)cc1F |r| Show InChI InChI=1S/C25H24BrClFN5O4S/c1-32-13-25(14-32,21-18(28)8-15(26)10-30-21)23(35)33-11-16(38(36,37)20-5-3-2-4-17(20)27)9-19(33)22(34)31-24(12-29)6-7-24/h2-5,8,10,16,19H,6-7,9,11,13-14H2,1H3,(H,31,34)/t16-,19+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	6.5	n/a
Genentech, Inc. US Patent					Assay Description Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...				US Patent US8822505 (2014) BindingDB Entry DOI: 10.7270/Q2CF9NTJ
					More data for this Ligand-Target Pair
Cathepsin S (Homo sapiens (Human))	BDBM130414 (US8822505, 14 | US8822505, 16) Show SMILES CN1CC(C1)(C(=O)N1C[C@@H](C[C@H]1C(=O)NC1(CC1)C#N)S(=O)(=O)c1ccccc1Cl)c1ncc(Br)cc1F |r| Show InChI InChI=1S/C25H24BrClFN5O4S/c1-32-13-25(14-32,21-18(28)8-15(26)10-30-21)23(35)33-11-16(38(36,37)20-5-3-2-4-17(20)27)9-19(33)22(34)31-24(12-29)6-7-24/h2-5,8,10,16,19H,6-7,9,11,13-14H2,1H3,(H,31,34)/t16-,19+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.525	n/a	n/a	n/a	n/a	6.5	n/a
Genentech, Inc. US Patent					Assay Description Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...				US Patent US8822505 (2014) BindingDB Entry DOI: 10.7270/Q2CF9NTJ
					More data for this Ligand-Target Pair
Cathepsin S (Homo sapiens (Human))	BDBM130414 (US8822505, 14 | US8822505, 16) Show SMILES CN1CC(C1)(C(=O)N1C[C@@H](C[C@H]1C(=O)NC1(CC1)C#N)S(=O)(=O)c1ccccc1Cl)c1ncc(Br)cc1F |r| Show InChI InChI=1S/C25H24BrClFN5O4S/c1-32-13-25(14-32,21-18(28)8-15(26)10-30-21)23(35)33-11-16(38(36,37)20-5-3-2-4-17(20)27)9-19(33)22(34)31-24(12-29)6-7-24/h2-5,8,10,16,19H,6-7,9,11,13-14H2,1H3,(H,31,34)/t16-,19+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.613	n/a	n/a	n/a	n/a	6.5	n/a
Genentech, Inc. US Patent					Assay Description Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...				US Patent US8822505 (2014) BindingDB Entry DOI: 10.7270/Q2CF9NTJ
					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM130414 (US8822505, 14 | US8822505, 16) Show SMILES CN1CC(C1)(C(=O)N1C[C@@H](C[C@H]1C(=O)NC1(CC1)C#N)S(=O)(=O)c1ccccc1Cl)c1ncc(Br)cc1F |r| Show InChI InChI=1S/C25H24BrClFN5O4S/c1-32-13-25(14-32,21-18(28)8-15(26)10-30-21)23(35)33-11-16(38(36,37)20-5-3-2-4-17(20)27)9-19(33)22(34)31-24(12-29)6-7-24/h2-5,8,10,16,19H,6-7,9,11,13-14H2,1H3,(H,31,34)/t16-,19+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	39.8	n/a	n/a	n/a	n/a	6.5	n/a
Genentech, Inc. US Patent					Assay Description Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...				US Patent US8822505 (2014) BindingDB Entry DOI: 10.7270/Q2CF9NTJ
					More data for this Ligand-Target Pair