BDBM130870 US8829199, 138

SMILES: Cc1nc2ccc(cc2n1)-n1ncc(C(=O)c2cc3c(NC(CO)CO)cccc3[nH]2)c1N

InChI Key: InChIKey=XPJRQSVFOCSTQP-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 130870   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM130870 (US8829199, 138) Show SMILES Cc1nc2ccc(cc2n1)-n1ncc(C(=O)c2cc3c(NC(CO)CO)cccc3[nH]2)c1N Show InChI InChI=1S/C23H23N7O3/c1-12-26-19-6-5-14(7-20(19)27-12)30-23(24)16(9-25-30)22(33)21-8-15-17(28-13(10-31)11-32)3-2-4-18(15)29-21/h2-9,13,28-29,31-32H,10-11,24H2,1H3,(H,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.20	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Seiyaku Kabushiki Kaisha; F. Hoffmann-La Roche AG US Patent					Assay Description The FGFR1-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...				US Patent US8829199 (2014) BindingDB Entry DOI: 10.7270/Q26T0KB8
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM130870 (US8829199, 138) Show SMILES Cc1nc2ccc(cc2n1)-n1ncc(C(=O)c2cc3c(NC(CO)CO)cccc3[nH]2)c1N Show InChI InChI=1S/C23H23N7O3/c1-12-26-19-6-5-14(7-20(19)27-12)30-23(24)16(9-25-30)22(33)21-8-15-17(28-13(10-31)11-32)3-2-4-18(15)29-21/h2-9,13,28-29,31-32H,10-11,24H2,1H3,(H,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.60	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Seiyaku Kabushiki Kaisha; F. Hoffmann-La Roche AG US Patent					Assay Description The FGFR3-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...				US Patent US8829199 (2014) BindingDB Entry DOI: 10.7270/Q26T0KB8
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM130870 (US8829199, 138) Show SMILES Cc1nc2ccc(cc2n1)-n1ncc(C(=O)c2cc3c(NC(CO)CO)cccc3[nH]2)c1N Show InChI InChI=1S/C23H23N7O3/c1-12-26-19-6-5-14(7-20(19)27-12)30-23(24)16(9-25-30)22(33)21-8-15-17(28-13(10-31)11-32)3-2-4-18(15)29-21/h2-9,13,28-29,31-32H,10-11,24H2,1H3,(H,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Seiyaku Kabushiki Kaisha; F. Hoffmann-La Roche AG US Patent					Assay Description The FGFR2-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...				US Patent US8829199 (2014) BindingDB Entry DOI: 10.7270/Q26T0KB8
					More data for this Ligand-Target Pair