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SMILES: O=c1cc([nH]c2c(cccc12)-c1cn(Cc2ccccc2)nn1)N1CCOCC1

InChI Key: InChIKey=LWPBOAMTACBAGU-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 132091   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM132091
PNG
(US8841288, CL5)
Show SMILES O=c1cc([nH]c2c(cccc12)-c1cn(Cc2ccccc2)nn1)N1CCOCC1
Show InChI InChI=1S/C22H21N5O2/c28-20-13-21(26-9-11-29-12-10-26)23-22-17(7-4-8-18(20)22)19-15-27(25-24-19)14-16-5-2-1-3-6-16/h1-8,13,15H,9-12,14H2,(H,23,28)
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Similars
US Patent
n/an/a 260n/an/an/an/an/a25



Universtà Degli Studi di Torino; Università Degli Studi del Piemonte Orientale “Amedeo Avogadro”

US Patent


Assay Description
Some compounds of formula (I) described herein were assayed in vitro for their ability to inhibit the lipid kinase activity of PI3Ks, by using a non-...

US Patent US8841288 (2014)


BindingDB Entry DOI: 10.7270/Q2RJ4H5X
More data for this
Ligand-Target Pair