BDBM133773 US8846699, 91

SMILES: Fc1cc(Br)ccc1Nc1ncnc2cc(OCC3CNC(=O)O3)c(NC(=O)C=C)cc12

InChI Key: InChIKey=PJTNXYFSQNXMMA-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 133773   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM133773 (US8846699, 91) Show SMILES Fc1cc(Br)ccc1Nc1ncnc2cc(OCC3CNC(=O)O3)c(NC(=O)C=C)cc12 Show InChI InChI=1S/C21H17BrFN5O4/c1-2-19(29)27-17-6-13-16(7-18(17)31-9-12-8-24-21(30)32-12)25-10-26-20(13)28-15-4-3-11(22)5-14(15)23/h2-7,10,12H,1,8-9H2,(H,24,30)(H,27,29)(H,25,26,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	17	n/a	n/a	n/a	n/a	7.4	25
Hanmi Pharm. Co., Ltd. US Patent					Assay Description EGFR1 (HER-1) enzyme assay was carried out by using Tyrosine Kinase Assay Kit Green. The entire assay was conducted in accordance with EGFR PTK inhib...				US Patent US8846699 (2014) BindingDB Entry DOI: 10.7270/Q2KW5DRK
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM133773 (US8846699, 91) Show SMILES Fc1cc(Br)ccc1Nc1ncnc2cc(OCC3CNC(=O)O3)c(NC(=O)C=C)cc12 Show InChI InChI=1S/C21H17BrFN5O4/c1-2-19(29)27-17-6-13-16(7-18(17)31-9-12-8-24-21(30)32-12)25-10-26-20(13)28-15-4-3-11(22)5-14(15)23/h2-7,10,12H,1,8-9H2,(H,24,30)(H,27,29)(H,25,26,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	587	n/a	n/a	n/a	n/a	7.4	25
Hanmi Pharm. Co., Ltd. US Patent					Assay Description VEGFR2 (KDR, Proquinase) enzyme assay (auto-phosphorylation assay) was carried out by using Tyrosine Kinase Assay Kit Green (Panvera). The entire ass...				US Patent US8846699 (2014) BindingDB Entry DOI: 10.7270/Q2KW5DRK
					More data for this Ligand-Target Pair